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Ionis Pharmaceuticals Inc (IONS) AI Forecast

Our AI analyzed Ionis Pharmaceuticals Inc. Create a free account and follow it to see the 90-day price prediction.

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$IONS Neutral Signal Full forecast available

Ionis Pharmaceuticals Inc (IONS) Stock Forecast Sept. 24, 2026


Ionis Pharmaceuticals Inc (IONS) AI Stock Price Forecast & Investment Analysis

Ionis Pharmaceuticals Inc Stock Price Chart and Technical Analysis

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Ionis Pharmaceuticals Inc (IONS) - Comprehensive Stock Analysis & Investment Research

Deep dive into Ionis Pharmaceuticals Inc's business profile, financial performance, AI predictions, and competitive positioning to make informed investment decisions.

Analysis updated on September 24, 2026 (UTC)

Ionis Pharmaceuticals Inc Investment Summary

When evaluating whether Ionis Pharmaceuticals Inc (IONS) represents a compelling investment opportunity, investors must consider multiple factors including the company's financial health, market position, growth prospects, and what our AI-powered predictive models suggest about its near-term price trajectory.

Company Profile

Ionis Pharmaceuticals Inc (IONS) operates within the Life Sciences sector, specifically in the Pharmaceutical Preparations industry. . With a market capitalization of $7 billion, the company is a mid-cap stock that typically offers a balance between growth potential and established business operations.

Financial Performance Analysis

Our comprehensive financial analysis covers Ionis Pharmaceuticals Inc's revenue, profitability metrics, balance sheet strength, and cash flow generation...

AI Price Predictions

Get AI-powered 7-day, 30-day and 90-day price forecasts for Ionis Pharmaceuticals Inc along with confidence scores and detailed analysis...

Investment Considerations

Expert analysis of whether Ionis Pharmaceuticals Inc is suitable for your investment objectives, risk tolerance, and time horizon...

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Corporate Identity

Ionis Pharmaceuticals Inc (Stock Symbol: IONS) is a prominent company operating within the Life Sciences sector, with a specific focus on the Pharmaceutical Preparations industry. The company's shares are publicly traded on the Nasdaq exchange.

Leadership & Workforce

Detailed information about Ionis Pharmaceuticals Inc's leadership team, workforce size, and organizational structure...

Market Classification

Market capitalization analysis and stock classification (mega-cap, large-cap, mid-cap, small-cap) for Ionis Pharmaceuticals Inc...

Sector & Industry Analysis

In-depth sector dynamics and industry context for Ionis Pharmaceuticals Inc...

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Revenue & Growth Analysis

Ionis Pharmaceuticals Inc generates annual revenues of $265 million , representing an emerging company in its growth phase.

Profitability Metrics

Net profit margin, gross margin, and operating margin analysis for Ionis Pharmaceuticals Inc...

Market Valuation

P/E ratio, price-to-book, and valuation multiples for Ionis Pharmaceuticals Inc...

Return Metrics

Return on equity (ROE), return on assets (ROA), and capital efficiency for Ionis Pharmaceuticals Inc...

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AI ANALYSIS AVAILABLE

Unlock Ionis Pharmaceuticals Inc's AI Price Forecast

Across our coverage, the out-of-sample test on 4537 stocks from 2025-01-06 to 2026-06-09 produced a positive net return in 73.7% of rebalance periods (factor-neutral book, net of estimated costs). Full backtest report

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Strategic Market Position

Ionis Pharmaceuticals Inc strategically competes in the highly dynamic Pharmaceutical Preparations marketplace. As a mid-cap company, it occupies an attractive position balancing growth potential with established operations. Mid-caps often represent the 'sweet spot' for investors seeking companies that have proven their business models but still have meaningful runway for expansion. These companies are large enough to have competitive advantages but nimble enough to adapt quickly to market changes.

Industry Competitive Landscape

Ionis Pharmaceuticals Inc competes within the Life Sciences sector, navigating the competitive dynamics and market forces specific to this industry. The company's competitive position depends on its ability to differentiate through product quality, cost efficiency, customer relationships, or other strategic advantages relevant to its specific market segment.

Operational Efficiency

The company currently shows negative free cash flow of $-561 million . Negative free cash flow may reflect heavy investment in growth, working capital needs, or operational challenges. This is common for high-growth companies investing aggressively but warrants attention for mature businesses.

Margin & Pricing Power Analysis

The company maintains a 94.0% gross margin which reflects strong pricing power and/or low direct production costs relative to revenue. Gross margins are only comparable within an industry, so read this level against the company's peers rather than the market as a whole.

Operating margin of -224.0% demonstrates how efficiently the company converts revenues into operating profits after accounting for all operating expenses including research and development, sales and marketing, and general administrative costs. Operating margin compression relative to gross margin suggests high operating expenses that may warrant efficiency improvements or reflect necessary growth investments.

Asset Utilization Efficiency

Asset turnover ratio of 0.09x indicates lower asset turnover that may reflect the industry's capital-intensive nature or potentially underutilized assets. Companies with low turnover typically depend on strong margins to generate adequate returns on capital.

Financial Strength & Leverage

Current ratio of 7.89 demonstrates strong short-term liquidity with current assets significantly exceeding current liabilities. This provides a substantial buffer for meeting near-term obligations and handling unexpected financial needs.

Ionis Pharmaceuticals Inc (IONS) Fundamental Analysis & Insider Trading Data (Quarterly Financial Reports)

Comprehensive quarterly financial data, earnings trends, insider transactions, and institutional holdings for Ionis Pharmaceuticals Inc stock analysis.

Deep dive into Ionis Pharmaceuticals Inc's financial health, valuation metrics, and operational efficiency to make informed investment decisions.

Understanding Valuation Metrics

What these metrics mean: Valuation metrics help determine if Ionis Pharmaceuticals Inc stock is fairly priced compared to its earnings, assets, and market position.

How to read them: Lower P/E ratios may indicate undervalued stocks, while higher ratios suggest growth expectations. P/B ratio compares market value to book value.

For Ionis Pharmaceuticals Inc:

P/B Ratio 16.60x
Market Cap $7.30B
EPS $-3.77
Book Value/Share $2.65
Revenue/Share $1.60
FCF/Share $-3.37
Understanding Profitability Metrics

What these metrics mean: These ratios measure how efficiently Ionis Pharmaceuticals Inc converts revenue into profit and generates returns for shareholders.

How to read them: Higher ROE/ROA indicate better management efficiency. Margin percentages show profit at different operational levels.

For Ionis Pharmaceuticals Inc: An ROE of -128.5% indicates room for improvement in shareholder value creation.

ROE -128.5%
ROA -18.9%
ROIC -22.2%
Gross Margin 94.0%
Operating Margin -224.0%
Net Margin -213.0%
EBT Margin -211.8%
Tax Rate -0.6%
Understanding Financial Health Metrics

What these metrics mean: These ratios assess Ionis Pharmaceuticals Inc's ability to meet short-term obligations and manage debt levels effectively.

How to read them: Current ratio >2 is generally good, Quick ratio >1 shows strong liquidity. Lower D/E ratios indicate conservative debt management.

For Ionis Pharmaceuticals Inc: A current ratio of 7.89 indicates strong liquidity.

Current Ratio 7.89x
Quick Ratio 7.73x
D/E Ratio 5.81x
Financial Leverage 6.81x
Interest Coverage -22.2x
Working Capital $2.18B
Understanding Cash Flow Metrics

What these metrics mean: Cash flow metrics reveal Ionis Pharmaceuticals Inc's ability to generate cash from operations and fund growth initiatives.

How to read them: Positive operating cash flow is crucial. Free cash flow shows money available for dividends, buybacks, or investments.

For Ionis Pharmaceuticals Inc: Free cash flow of $-561M indicates cash challenges that need attention.

Operating Cash Flow -$496M
Free Cash Flow -$561M
Capital Spending -$64M
FCF/Sales -211.4%
CapEx/Sales 24.3%
Understanding Operational Efficiency Metrics

What these metrics mean: These ratios measure how effectively Ionis Pharmaceuticals Inc uses its assets and manages working capital.

How to read them: Higher turnover ratios indicate efficient asset utilization. Shorter collection periods show effective credit management.

For Ionis Pharmaceuticals Inc: An asset turnover of 0.09x suggests room for improvement in asset utilization.

Asset Turnover 0.09x
Inventory Turnover 0.3x
Fixed Assets Turnover 1.7x
Days Inventory 1158 days
Payables Period 1087 days
Understanding Financial Statement Data

What these metrics mean: Key figures from Ionis Pharmaceuticals Inc's income statement and balance sheet showing absolute financial performance.

How to read them: Revenue shows business scale, while margins indicate profitability. Balance sheet items reveal financial structure.

For Ionis Pharmaceuticals Inc: With annual revenue of $265M, Ionis Pharmaceuticals Inc demonstrates solid business size.

Income Statement
Total Revenue $265M
Operating Income -$594M
Net Income -$565M
SG&A Expense $528M
Cost of Goods Sold $16M
Balance Sheet Highlights (USD millions)
Total Current Assets $2.49B (83.2% of assets)
Cash & Short-term Investments $350M (11.7% of assets)
Inventory $51M (1.7% of assets)
Total Liabilities $2.55B (85.3% of assets)
Short-term Debt $268M (8.9% of assets)
Dividend & Shareholder Information
Shares Outstanding 166M

Latest Ionis Pharmaceuticals Inc Stock News & Market Analysis

Breaking news, analyst reports, and market updates affecting Ionis Pharmaceuticals Inc (IONS) stock price and investment outlook.

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Where IONS sits on the market map

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Ionis Pharmaceuticals Inc Industry Peers - Pharmaceutical Preparations

Companies classified under the same SEC industry code as Ionis Pharmaceuticals Inc (Pharmaceutical Preparations): 60 common-stock issuers with a forecast this week, one row per issuer, largest first. This is a classification match, not a curated list of competitors.

Company Ticker Symbol 90-Day AI Forecast (Alpha) Market Cap (USD M) P/E Ratio P/B Ratio
IONS ██% $7.30B x 16.6x
LLY ██% $1.08T 40.6x 110.2x
JNJ ██% $648.67B 30.8x 7.6x
ONC ██% $539.52B x 104.3x
ABBV ██% $468.43B 74.2x x
MRK ██% $365.34B 115.1x 8.7x
NVS ██% $272.31B x x
GSK ██% $214.26B x x
ABT ██% $180.26B 28.6x 3.5x
PFE ██% $160.62B 37.1x 1.9x
VRTX ██% $130.87B 29.7x 6.5x
BMY ██% $125.63B 13.5x 5.6x
REGN ██% $82.55B 19.1x 2.6x
SNY ██% $50.80B x x
TEVA ██% $45.46B 64.3x 5.9x
ALNY ██% $33.40B x 24.7x
RPRX ██% $33.15B 40.7x 4.9x
ATHE ██% $32.40B x x
TAK ██% $29.93B x x
ZLAB ██% $29.68B x 48.9x
ZTS ██% $29.59B 11.3x 9.4x
ROIV ██% $26.60B x 6.3x
INSM ██% $25.84B x 34.1x
UTHR ██% $20.99B 16.0x 3.3x
VTRS ██% $19.66B x x
JAZZ ██% $15.25B 16.2x 3.2x
ASND ██% $14.30B x x
SMMT ██% $13.12B x 20.8x
BBIO ██% $12.96B x x
CORT ██% $12.81B x 18.2x
HCM ██% $12.54B x 10.1x
BMRN ██% $11.88B x 1.9x
KNSA ██% $11.87B x 19.6x
MDGL ██% $11.85B x 22.6x
ELAN ██% $11.17B x 1.7x
RDY ██% $10.34B x x
AXSM ██% $10.27B x 123.3x
ARWR ██% $9.33B x 20.1x
CYTK ██% $9.13B x x
PTGX ██% $8.98B x 10.7x
PRAX ██% $7.88B x 5.9x
SYRE ██% $7.77B x 7.1x
GPCR ██% $7.71B x 5.7x
ABVX ██% $7.39B x x
ALKS ██% $6.84B x 3.8x
LEGN ██% $6.82B x x
RYTM ██% $6.76B x 65.7x
BLRX ██% $6.68B x x
BLTE ██% $6.67B x 8.7x
AMRX ██% $6.32B x x
LQDA ██% $6.04B x 31.0x
LGND ██% $5.95B 30.2x 6.2x
MIRM ██% $5.80B x x
AMRN ██% $5.64B x 12.7x
TVTX ██% $5.64B x 230.0x
COGT ██% $5.45B x 10.2x
PTCT ██% $5.20B x x
ERAS ██% $5.08B x 14.0x
DNTH ██% $5.07B x 4.3x
VKTX ██% $4.86B x 11.9x
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Frequently Asked Questions - Ionis Pharmaceuticals Inc Stock Forecast

How accurate are Ionis Pharmaceuticals Inc stock predictions?

A per-ticker accuracy statistic for IONS is published only once its sample size is known. Across our coverage, the out-of-sample test on 4537 stocks from 2025-01-06 to 2026-06-09 produced a positive net return in 73.7% of rebalance periods (factor-neutral book, net of estimated costs). Full backtest report

What factors influence Ionis Pharmaceuticals Inc stock price forecasts?

Our analysis considers Ionis Pharmaceuticals Inc's financial metrics, Life Sciences sector trends, market sentiment, technical indicators, earnings data, and macroeconomic factors affecting stock performance.

Is Ionis Pharmaceuticals Inc a good investment in 2026?

Based on our AI analysis, Ionis Pharmaceuticals Inc shows potential for various market scenarios. Consider your risk tolerance, investment timeline, and portfolio diversification before making investment decisions.

How often are Ionis Pharmaceuticals Inc forecasts updated?

Ionis Pharmaceuticals Inc forecasts are refreshed on trading days as the daily model run completes. The forecast on this page was produced on September 24, 2026.

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