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Stock comparison · Signal date 2026-11-06

IONS vs LGND: stock comparison and AI forecast

Ionis Pharmaceuticals Inc (IONS) and Ligand Pharmaceuticals Inc (LGND) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
Nasdaq · Pharmaceutical Preparations

IONS Ionis Pharmaceuticals Inc

Price
$39.42 -48.1% · 6M
Market Cap
$6.55B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Nasdaq · Pharmaceutical Preparations

LGND Ligand Pharmaceuticals Inc

Market Cap
$6.12B
P/E Ratio
116.9x
Size
mid-cap
AI Forecast
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

IONS · LGND

Key facts

  • IONS and LGND have similar market capitalizations ($6.55B and $6.12B).
  • LGND turns 14.8% of its revenue into net income, against -213.0% for IONS.
  • IONS carries 5.81 times debt per unit of equity, against 1.33 times for LGND.
  • Both companies share the SEC industry classification Pharmaceutical Preparations.
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricIONSLGND
Market Cap$6.55B$6.12B
P/E Ratio–116.89x
P/B Ratio14.90x6.37x
EPS$-3.77$2.62
Book Value/Share$2.65$48.08
Revenue/Share$1.60$17.34
FCF/Share$-3.37$4.53

Profitability & Margins

MetricIONSLGND
ROE-128.5%5.3%
ROA-18.9%2.3%
ROIC-22.2%1.4%
Gross Margin94.0%–
Operating Margin-224.0%6.9%
Net Margin-213.0%14.8%
EBT Margin-211.8%15.2%
Tax Rate-0.6%2.4%

Financial Health

MetricIONSLGND
Current Ratio7.89x1.22x
Quick Ratio7.73x1.19x
D/E Ratio5.81x1.33x
Financial Leverage6.81x2.33x
Interest Coverage-22.1x–
Working Capital$2.18B$108M

Cash Flow

MetricIONSLGND
Operating Cash Flow-$496M$91M
Free Cash Flow-$561M$91M
Capital Spending-$64M-$410K
OCF Growth YoY–185.2%
FCF Growth YoY–194.6%
FCF/Sales-211.4%26.1%
CapEx/Sales24.3%0.1%

Operational Efficiency

MetricIONSLGND
Asset Turnover0.09x0.15x
Receivables Turnover–4.2x
Inventory Turnover0.3x–
Fixed Assets Turnover1.7x93.5x
Days Sales Outstanding–88 days
Days Inventory1158 days–
Payables Period1087 days–

Income Statement

MetricIONSLGND
Total Revenue$265M$347M
Operating Income-$594M$24M
Net Income-$565M$51M
R&D Expense–$23M
SG&A Expense$528M–
Cost of Goods Sold$16M–

Dividend & Shareholder Information

MetricIONSLGND
Shares Outstanding166M20M
Net Income Growth–5.9%
EPS Growth–30.4%
FAQ

IONS vs LGND: stock comparison and AI forecast

Which is bigger, IONS or LGND?

IONS and LGND have similar market capitalizations ($6.55B and $6.12B).

Which one does Intratio's AI model rank higher, IONS or LGND?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.