Ionis Pharmaceuticals Inc (IONS) Stock Forecast Nov. 6, 2026
Analysis updated on Nov. 6, 2026 (UTC) · Alpha · vs marketSwitch to Total · Nasdaq
Ionis Pharmaceuticals Inc (IONS) stock forecast summary
Our AI scores Ionis Pharmaceuticals Inc every trading day against every stock it covers. Create a free account and follow it to see its rating and price target.
Ionis Pharmaceuticals Inc is a mid-cap company with a market capitalization of $6.55B. It ranks number 47 by market capitalization among the 60 Pharmaceutical Preparations issuers in our coverage with a current forecast.
For IONS, the Spearman rank correlation between our 90-day forecasts and the returns that followed is 21.0%, measured on 357 forecast dates between 2022-08-19 and 2026-08-07 on this stock's own recent history. A rank correlation runs from -100% to +100%: it measures whether higher forecasts were followed by higher returns, and a value near zero or below means the model has shown little skill on this stock. On the 30-day forecasts the same correlation is 12.0%, measured on 400 forecast dates between 2022-08-19 and 2026-10-07. Across our coverage, the out-of-sample test on 4629 stocks from 2025-01-06 to 2026-08-04 produced a positive net return in 92.9% of rebalance periods (factor-neutral book, net of estimated costs). Full backtest report
Expected return relative to the market over the horizon: a positive alpha means the model expects the stock to beat the market, whatever the market does. Ratings: strong buy ≥ +3.1%, buy ≥ +1.5%, sell < -0.5%, strong sell < -1.8% (top 15%, next 20%, middle 30%, next 20%, bottom 15% of the 2026-11-06 signals)
A free account shows the exact forecast, rating and rank of 3 tickers you follow, IONS included.
IONS price chart and AI forecast
How IONS ranks among 5150 stocks
90D Alpha forecasts of every company scored, cut into five relative ratings at the 15th, 35th, 65th and 85th percentiles (dashed lines).
Ionis Pharmaceuticals Inc (IONS) fundamentals
Trailing twelve months. The industry median and the rank (1 = highest) are taken over the Pharmaceutical Preparations peers listed below that report each metric.
Valuation & Market
| Metric | IONS | Rank |
|---|---|---|
| Market Cap | $6.55B | 47/60 |
| P/B Ratio | 14.90x | 9/42 |
| EPS | $-3.77 | – |
| Book Value/Share | $2.65 | – |
| Revenue/Share | $1.60 | – |
| FCF/Share | $-3.37 | – |
Profitability & Margins
| Metric | IONS | Rank |
|---|---|---|
| ROE | -128.5% | 33/38 |
| ROA | -18.9% | 32/42 |
| ROIC | -22.2% | 33/44 |
| Gross Margin | 94.0% | 5/36 |
| Operating Margin | -224.0% | 35/38 |
| Net Margin | -213.0% | 32/35 |
| EBT Margin | -211.8% | 43/46 |
| Tax Rate | -0.6% | – |
Financial Health
| Metric | IONS | Rank |
|---|---|---|
| Current Ratio | 7.89x | 13/58 |
| Quick Ratio | 7.73x | 1/43 |
| D/E Ratio | 5.81x | 3/47 |
| Financial Leverage | 6.81x | 3/47 |
| Interest Coverage | -22.1x | 26/33 |
| Working Capital | $2.18B | 17/58 |
Cash Flow
| Metric | IONS | Rank |
|---|---|---|
| Operating Cash Flow | -$496M | 55/59 |
| Free Cash Flow | -$561M | 47/50 |
| Capital Spending | -$64M | 27/50 |
| FCF/Sales | -211.4% | 40/42 |
| CapEx/Sales | 24.3% | 3/42 |
Operational Efficiency
| Metric | IONS | Rank |
|---|---|---|
| Asset Turnover | 0.09x | 37/39 |
| Inventory Turnover | 0.3x | 34/35 |
| Fixed Assets Turnover | 1.7x | 37/41 |
| Days Inventory | 1158 days | 2/35 |
| Payables Period | 1087 days | 1/24 |
Income Statement
| Metric | IONS | Rank |
|---|---|---|
| Total Revenue | $265M | 43/46 |
| Operating Income | -$594M | 47/50 |
| Net Income | -$565M | 39/46 |
| SG&A Expense | $528M | 33/40 |
| Cost of Goods Sold | $16M | 35/37 |
Dividend & Shareholder Information
| Metric | IONS | Rank |
|---|---|---|
| Shares Outstanding | 166M | – |
Balance Sheet Highlights (USD millions)
| Total Current Assets | $2.49B | 83.2% of assets |
| Cash & Short-term Investments | $350M | 11.7% of assets |
| Inventory | $51M | 1.7% of assets |
| Total Liabilities | $2.55B | 85.3% of assets |
| Short-term Debt | $268M | 8.9% of assets |
IONS quarterly financials and insider trading
Ionis Pharmaceuticals Inc (IONS) industry peers
Companies classified under the same SEC industry code as Ionis Pharmaceuticals Inc (Pharmaceutical Preparations): 60 common-stock issuers with a forecast this week, one row per issuer, largest first. This is a classification match, not a curated list of competitors.
Reveal all forecasts · See exact % predictions for all competitors
Sign up free| Company | 90-Day AI Forecast (Alpha) | Market Cap |
|---|---|---|
| IONS Ionis Pharmaceuticals Inc | $6.55B | |
| LLY Eli Lilly & Co | $1.28T | |
| JNJ Johnson & Johnson | $664.95B | |
| ABBV Abbvie Inc. | $514.78B | |
| MRK Merck & Co., Inc. | $362.01B | |
| NVS Novartis Ag | $310.17B | |
| AZN Astrazeneca Plc | $288.97B | |
| ABT Abbott Laboratories | $191.15B | |
| NVO Novo Nordisk A S | $179.14B | |
| PFE Pfizer Inc | $167.51B | |
| VRTX Vertex Pharmaceuticals Inc / Ma | $137.50B | |
| BMY Bristol Myers Squibb Co | $127.02B | |
| SNY Sanofi | $115.97B | |
| GSK Gsk Plc | $101.70B | |
| REGN Regeneron Pharmaceuticals, Inc. | $93.11B | |
| TAK Takeda Pharmaceutical Co Ltd | $66.19B | |
| TEVA Teva Pharmaceutical Industries Ltd | $49.65B | |
| ONC Beone Medicines Ltd. | $46.26B | |
| GMAB Genmab A/S | $34.50B | |
| ZTS Zoetis Inc. | $33.93B | |
| RPRX Royalty Pharma Plc | $28.82B | |
| ROIV Roivant Sciences Ltd. | $26.45B | |
| INSM Insmed Inc | $25.10B | |
| UTHR United Therapeutics Corp | $24.11B | |
| VTRS Viatris Inc | $22.87B | |
| ALNY Alnylam Pharmaceuticals, Inc. | $20.89B | |
| ASND Ascendis Pharma A/S | $16.86B | |
| JAZZ Jazz Pharmaceuticals Plc | $15.24B | |
| BBIO Bridgebio Pharma, Inc. | $14.47B | |
| SMMT Summit Therapeutics Inc. | $13.03B | |
| ELAN Elanco Animal Health Inc | $12.86B | |
| RDY Dr Reddys Laboratories Ltd | $12.44B | |
| BMRN Biomarin Pharmaceutical Inc | $10.85B | |
| MDGL Madrigal Pharmaceuticals, Inc. | $9.24B | |
| TGTX Tg Therapeutics, Inc. | $9.20B | |
| SYRE Spyre Therapeutics, Inc. | $9.16B | |
| PTGX Protagonist Therapeutics, Inc | $8.54B | |
| ARWR Arrowhead Pharmaceuticals, Inc. | $8.22B | |
| CORT Corcept Therapeutics Inc | $7.87B | |
| PRAX Praxis Precision Medicines, Inc. | $7.75B | |
| RYTM Rhythm Pharmaceuticals, Inc. | $7.73B | |
| ALKS Alkermes Plc. | $7.70B | |
| ABVX Abivax S.A. | $7.50B | |
| CYTK Cytokinetics Inc | $7.46B | |
| KNSA Kiniksa Pharmaceuticals International, Plc | $6.94B | |
| AXSM Axsome Therapeutics, Inc. | $6.93B | |
| ORKA Oruka Therapeutics, Inc. | $6.81B | |
| AMRX Amneal Pharmaceuticals, Inc. | $6.43B | |
| MIRM Mirum Pharmaceuticals, Inc. | $6.07B | |
| BLTE Belite Bio, Inc | $6.07B | |
| LGND Ligand Pharmaceuticals Inc | $5.98B | |
| MANE Veradermics, Inc | $5.80B | |
| SUPN Supernus Pharmaceuticals, Inc. | $5.56B | |
| COGT Cogent Biosciences, Inc. | $5.49B | |
| PTCT Ptc Therapeutics, Inc. | $5.47B | |
| EWTX Edgewise Therapeutics, Inc. | $4.89B | |
| DNTH Dianthus Therapeutics, Inc. /De/ | $4.64B | |
| ERAS Erasca, Inc. | $4.64B | |
| TVTX Travere Therapeutics, Inc. | $4.44B | |
| LEGN Legend Biotech Corp | $4.17B |
Where IONS sits on the market map
Ionis Pharmaceuticals Inc (IONS) stock news
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Ionis Pharmaceuticals Inc (IONS) stock forecast FAQ
What is the Ionis Pharmaceuticals Inc (IONS) stock forecast?
Our AI scores Ionis Pharmaceuticals Inc every trading day against every stock it covers. Create a free account and follow it to see its rating and price target.
How accurate are Ionis Pharmaceuticals Inc stock predictions?
For IONS, the Spearman rank correlation between our 90-day forecasts and the returns that followed is 21.0%, measured on 357 forecast dates between 2022-08-19 and 2026-08-07 on this stock's own recent history. A rank correlation runs from -100% to +100%: it measures whether higher forecasts were followed by higher returns, and a value near zero or below means the model has shown little skill on this stock. On the 30-day forecasts the same correlation is 12.0%, measured on 400 forecast dates between 2022-08-19 and 2026-10-07. Across our coverage, the out-of-sample test on 4629 stocks from 2025-01-06 to 2026-08-04 produced a positive net return in 92.9% of rebalance periods (factor-neutral book, net of estimated costs). Full backtest report
How often are Ionis Pharmaceuticals Inc forecasts updated?
Ionis Pharmaceuticals Inc forecasts are refreshed on trading days as the daily model run completes. The forecast on this page was produced on Nov. 6, 2026.
Which companies are Ionis Pharmaceuticals Inc's industry peers?
60 issuers in our coverage, IONS included, share the SEC industry code Pharmaceutical Preparations. The largest are: Eli Lilly & Co (LLY), Johnson & Johnson (JNJ), Abbvie Inc. (ABBV), Merck & Co., Inc. (MRK), Novartis Ag (NVS), Astrazeneca Plc (AZN).
This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.